产品号: C100-005

批号: 69418

产品详情:

MERS-CoV, also known as NCoV (novel coronavirus) is a positive sense single stranded RNA virus that causes Middle East respiratory syndrome (MERS). This respiratory virus was first identified in June 2012 in Jeddah, Saudi Arabia¹, and while most cases have occurred in the Arabian Peninsula, is spread to 27 countries have reported cases since 2012, leading to 858 known deaths due to the infection and related complications^1,2,3. MERS-CoV expresses a trimeric spike glycoprotein on the surface the virus, which is comprised of S1 and S2 domains. Within the S1 domain is the receptor binding domain (RBD) that is responsible for binding to the host receptor DPP4⁴, allowing the virus to enter permissive cells. The predicted molecular weight is 150 kDa. The observed molecular weight may differ from predicted due to post translational modifications.

产品累呗: Recombinant Protein

病毒株: MERS Jordan

相似产品名称: MERS-CoV, MERS Coronavirus, MERS-CoV Spike, Coronavirus Spike Protein, MERS, Middle East respiratory syndrome coronavirus, EMC/2012

表达宿主: CHO

蛋白标签: C- terminal Strep-His-Avi

纯度: >95% by SDS-PAGE

生物安全等级: BSL-2

应用: ELISA, Western Blot, SDS-PAGE, immunogen. Specific conditions should be optimized by end user.

制剂: PBS

存储条件: 4°C for immediate use, -80°C for long-term storage. Avoid repeated freeze thaw cycles.

运输条件: Dry Ice

目的用途: For research use only. Not intended for human, therapeutic, or diagnostic use. Buyer may not modify, sell, or transfer product for commercial use without written permission from Eliteimmune.

参考文献:

1.      Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill. 2012

2.     Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012

3.     de Groot RJ, Baker SC, Baric RS, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV); Announcement of the Coronavirus Study Group. J Virol. 2013

4.     Raj VS et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature. 2013.  

Alternative Names:

MERS-CoV, MERS Coronavirus, MERS-CoV Spike, Coronavirus Spike Protein, MERS, Middle East respiratory virus