产品号: C100-003 

批号: 26389 

浓度: 1.45 mg/mL 

产品类别: Recombinant Protein 

病毒株: Wuhan-Hu-1 (GenBank: MN908947) 

表达宿主: CHO cells 

蛋白标签: C- terminal Histidine tag (8x-His)   

纯度: >95% by SDS-PAGE Biosafety 

生物安全等级: BSL-1 Applications: ELISA, Western Blot, SDS-PAGE, immunogen. Specific conditions should be optimized by end user. Formulation: PBS supplemented with 10% glycerol 

存储条件: 4°C for immediate use, -80°C for long-term storage. Avoid repeated freeze thaw cycles. 

运输条件: Dry Ice

相似产品名称: SARS-CoV2 receptor binding domain, 2019-nCoV RBD, 2019-nCoV receptor binding domain, SARS-CoV-2 Spike protein, SARS-CoV-2 S1, Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) 

产品详情: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a positive sense RNA virus responsible for the COVID-19 pandemic. SARS-CoV-2 expresses a trimeric spike glycoprotein on the surface the virus, which is comprised of S1 and S2 domains. Within the S1 domain is the receptor binding domain (RBD) that is responsible for binding to the host receptor angiotensin-converting enzyme 2 (ACE2), and allowing the virus to enter permissive cells1,2. Mutations within the RBD can also lead to decreased affinity of neutralizing antibodies to binding to the virus.3 Notes: Predicted molecular weight is 33.2 kDa. The observed molecular weight may differ from predicted due to post translational modifications. 

参考文献: 

1. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Yan et al. Science 2020.

2. Structure of SARS-CoV-2 Spike receptor-binding domain bound to the ACE2 receptor. Lan J et al. Nature 2020.

3. Greaney et al. Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies., Cell Host Microbe. 2021 Intended Use: For research use only. Not intended for human, therapeutic, or diagnostic use. Buyer may not modify, sell, or transfer product for commercial use without written permission from Eliteimmune.

Alternative Names:

SARS-CoV2 receptor binding domain, 2019-nCoV RBD, 2019-nCoV receptor binding domain, SARS-CoV-2 Spike protein, SARS-CoV-2 S1, Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)