Filoviruses are negative-sense single stranded RNA viruses, named for their filamentous-like structure. All filoviruses are classified as select agents within the United States and biosafety level 4 (BSL-4) pathogens by the world health organization (WHO)¹. Filoviruses can infect non-human primates and human and can cause sever diseases known as hemorrhagic fever. The mortality rate among filoviruses ranges from 30-90%. The most common filoviruses are Ebolavirus and Marburgvirus. Ebolaviruses contain Bundibugyo (BDBV), Reston (RESTV), Sudan (SUDV), Ebola (EBOV), and Tai Forest (TAFV). Marburgviruses include Marburg (MARV) and Ravn (RAVV)². Following the 2018 outbreak of Ebola, a vaccine was approved in 2019. However, this vaccine is largely strains specific and doesn’t offer cross protection against other filoviruses.
In support of efforts to develop broadly protective vaccines and therapeutics against Filoviruses, we offer a range of anti-viral assays are custom reagents. Our rVSV-pseudotype neutralization assay has been used in several publications for the screening antiviral molecules that block virus entry and replication. We also have soluble glycoprotein ectodomains of Ebola, Sudan, and Marburg for sale through our reagent program.
1. Centers for Disease Control and Prevention. Bioterrorism agents/diseases. https://emergency.cdc.gov/agent/agentlist-category.asp (accessed October 20, 2021).
2. Knipe DM, Howley PM, Griffin D, Lamb R, Martin M. Filoviridae: Marburg and Ebola viruses. Fields Virology, 5th ed.; Lippincott Williams & Wilkins: Philadelphia, PA, USA. 2006