Human anti-LukS-PV mAb (175)

Catalog Number: S200-004

Lot: See data sheet

Concentration: See data sheet

Description: Panton-Valentine leucocidin (PVL) is a cytotoxin released by Staphylococcus aureus and causes leukocyte lysis and tissue necrosis. PVL, is a bi-component exotoxin consisting of Leukocidin F (LukF) and Leukocidin S (LukS). Together, the two subunits join together to form beta barrel pores on the membrane of host immune cells such as white blood cells, monocytes and macrophages. The 33kDa structure of LukS has been solved in PDB 1T5R. Eliteimmune’s LukS targeting mAb 175 can be used in toxin neutralization assays (TNA) and is also a useful research tool for ELISAs.

Product Type: Human Monoclonal Antibody IgG1 subtype

Strain: Staphylococcus aureus 

Synonyms: Gamma-toxin, gamma toxin, gamma hemolysin, hemolysin, PVL, LukS-PVL, leucocidin, leucocidin S, Panton-Valentine leucocidin, LukS, pore forming toxin, exotoxin

Expression Host: CHO

Tag: None

Purity: Antibody is purified using immobilized protein G.

Applications: ELISA and toxin neutralization assays (TNA). Specific conditions should be optimized by end user.

Formulation: PBS

Storage: 4°C for immediate use, ≤-20°C for long-term storage. Avoid repeated freeze thaw cycles.

Shipped: Dry Ice

Intended Use: For research use only. Not intended for human, therapeutic, or diagnostic use. Buyer may not modify, sell, or transfer product for commercial use without written permission from Eliteimmune.

For customers located in the United States and EU, please purchase here.

Recommended Dilutions:

ELISA: Assay-dependent dilution. The antibody can be used for capture of LukS-PV in an indirect ELISA assay.

WB: Not recommended for Western Blot because the antibody recognizes conformational epitope.

Neutralization: Assay-dependent dilution

Cross Reactivity:  This antibody does not appear to cross react with S. aureus antigens Hla, LukF, SEA, or SEB, at the tested concentrations.

Alternative Names:

Gamma-toxin, gamma toxin, gamma hemolysin, hemolysin, PVL, LukS-PVL, leucocidin, leucocidin S, Panton-Valentine leucocidin, LukS, pore forming toxin, exotoxin